Conductance Changes Produced by Acetylcholine in Lipidic Membranes Containing a Proteolipid from Electrophorus

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Science  02 Apr 1971:
Vol. 172, Issue 3978, pp. 56-57
DOI: 10.1126/science.172.3978.56


Ultrathin lipidic membranes containing one ten-thousandth of a special proteolipid from electric organ of Electrophorus reacted to the addition of acetylcholine by a rapid and transient increase in conductance. Such a change was not induced by choline and is greatly reduced by a previous application of d-tubocurarine. These properties, resembling those from chemically excitable membranes, were not observed with another proteolipid from the same tissue.