Cycloheximide: Its Effects on Activity Are Dissociable from Its Effects on Memory

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Science  02 Apr 1971:
Vol. 172, Issue 3978, pp. 82-84
DOI: 10.1126/science.172.3978.82


Cycloheximide, when injected subcutaneously or intracerebrally, produces changes in the activity level of mice. Isocycloheximide, injected intracerebrally, produces identical effects on activity, but it does not produce inhibition of cerebral protein synthesis or amnesia. Amphetamine, in doses that can antagonize the amnesic action of cycloheximide, does not antagonize the effect of cycloheximide on activity. Effects of cycloheximide on activity do not appear to be responsible for its amnesic action.