Inhibition of Growth of Leukemia Cells by Enzymic Folate Depletion

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Science  09 Apr 1971:
Vol. 172, Issue 3979, pp. 161-162
DOI: 10.1126/science.172.3979.161


A new bacterial enzyme, designated as carboxypeptidase G1, inhibited growth of the L5178Y and L1210 murine leukemias, as well as the Walker carcinoma and the human lymphoblastoid line (RPMI 4265), propogated in vitro. This enzyme hydrolyzes the glutamate moiety from both oxidized and reduced folate forms, and thus it may prove to be of value in creating rapid folate depletion in vivo.

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