Activity of Δ8-and Δ9-Tetrahydrocannabinol and Related Compounds in the Mouse

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Science  09 Apr 1971:
Vol. 172, Issue 3979, pp. 165-167
DOI: 10.1126/science.172.3979.165


The 11-hydroxy metabolites of Δ8.- and Δ9-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Δ8- and Δ9-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussed

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