Alcohol Dependence Produced in Mice by Inhalation of Ethanol: Grading the Withdrawal Reaction

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Science  16 Apr 1971:
Vol. 172, Issue 3980, pp. 288-290
DOI: 10.1126/science.172.3980.288


Intoxicating blood levels of ethanol are maintained for several days in mice housed in an atmosphere of ethanol vapor. On removal from the alcohol, all the mice develop withdrawal signs. The signs can be graded to indicate the time course and intensity of the withdrawal reaction.

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