Bacteriophage and the Toxigenicity of Clostridium botulinum Type C

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Science  30 Apr 1971:
Vol. 172, Issue 3982, pp. 480-482
DOI: 10.1126/science.172.3982.480


Nontoxigenic and bacteriophage-sensitive bacterial cultures have been isolated from toxigenic Clostridium botulinum type C, strain 468C, after treatment with either ultraviolet light or acridine orange. Two bacteriophages, designated CEβ and CEγ, were isolated from toxigenic strain 468C. Both of these bacteriophages were capable of infecting the nontoxigenic type C cultures, but only bacteriophage CEβ was involved in the change from nontoxigenicity to toxigenicity.

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