Hycanthone Resistance: Development in Schistosoma mansoni

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Science  04 Jun 1971:
Vol. 172, Issue 3987, pp. 1057-1058
DOI: 10.1126/science.172.3987.1057


Following the administration of relatively high doses of the antischistosomal drug hycanthone to mice and hamsters infected with Schistosoma mansoni, a number of the worms survived. After a period of 6 to 12 months these parasites resumed production of viable eggs that gave rise to schistosomes that proved resistant to hycanthone and to two other related antischistosomal compounds. This drug resistance has remained stable for three subsequent generations of worms.