Hycanthone: A Frameshift Mutagen

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Science  04 Jun 1971:
Vol. 172, Issue 3987, pp. 1058-1060
DOI: 10.1126/science.172.3987.1058


Rapid spot-test screening of antischistosomal agents reveals that hycanthone is a potent frameshift mutagen while the closely related compound, miracil D, is nonmutagenic in Salmonella. Both hycanthone and miracil D are frameshift mutagens for T4 bacteriophage during growth in Escherichia coli.