Chemical Methylation of Inorganic Mercury with Methylcobalaiin, a Vitamin B12 Analog

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Science  18 Jun 1971:
Vol. 172, Issue 3989, pp. 1248-1249
DOI: 10.1126/science.172.3989.1248


Chemical methylation of mercuric chloride with methylcobalamin has been studied. Methylated mercury was detected by gas chromatography; and analysis of the products of the reaction by thin-layer chromatography revealed that the methylation proceeded at a remarkably high rate when methylcobalamin and inorganic mercury were mixed. Dimethylmercury was an initial product of the reaction.

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