Phospholipid—Calcium Phosphate Complex: Enhanced Calcium Migration in the Presence of Phosphate

See allHide authors and affiliations

Science  25 Jun 1971:
Vol. 172, Issue 3990, pp. 1339-1341
DOI: 10.1126/science.172.3990.1339


In the presence of acidic phospholipids, inorganic phosphate greatly enhances the net migration of calcium ions from the aqueous phase to the organic phase, an effect that does not occur at less than the physiological pH. The calcium complex in the organic phase is shown by electron microscopy to consist of spherules, composed of stoichiometric amount of calcium, inorganic phosphate, and phospholipid. The demonstration of complex formation between calcium phosphate and acidic phospholipids adds Support to the concept that phospholipids are involved in biological mineralization.

Stay Connected to Science