Euglena gracilis: Formation of Giant Mitochondria

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Science  16 Jul 1971:
Vol. 173, Issue 3993, pp. 252-254
DOI: 10.1126/science.173.3993.252


The addition of antimycin A (0.5 microgram per milliliter) to cultures of a bleached strain of Euglena gracilis in the logarithmic phase of growth on succinate as a carbon source results in (i) an interruption of growth for 24 hours and (ii) an increase in whole-cell respiration and the emergence of a novel succinoxidase activity within 2 to 4 hours. After 3 to 5 hours, the mitochondria enlarge, fuse, and form a sheathlike structure situated close to the periphery of the cell.