Free Radical Inhibitory Effect of Some Anticancer Compounds

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Science  06 Aug 1971:
Vol. 173, Issue 3996, pp. 537-539
DOI: 10.1126/science.173.3996.537


Conventional tests for polymerization initiated by free radicals indicate that alkylating agents vary in free radical inhibitory activity from negligible to moderately strong; antimetabolites from negligible to weak; hormones, steroids, and phenolics from very weak to very strong; and antibiotics from moderate to very strong. Vitamins A and C and copper, which potentiate the biological activity of some anticancer compounds, are relatively strong free radical inhibitors.

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