Human Lymphocyte Antigen Reactivity Modified by Neuraminidase

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Science  06 Aug 1971:
Vol. 173, Issue 3996, pp. 542-544
DOI: 10.1126/science.173.3996.542


Human lymphocytes treated with neuraminidase (from Vibrio cholera) are more susceptible to lysis with antiserums directed against HL-A antigens in the cytotoxicity test than are the corresponding cells incubated in buffer. Enzymetreated cells are also lysed by antibodies other than those directed against HL-A, but control cells are not. The extra sensitivity to antibody disappears after 2 to 6 days in tissue culture.

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