Histamine Augments Leukocyte Adenosine 3',5'-Monophosphate and Blocks Antigenic Histamine Release

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Science  20 Aug 1971:
Vol. 173, Issue 3998, pp. 743-745
DOI: 10.1126/science.173.3998.743


Extracellular histamine stimulates accumulation of adenosine 3',5'-monophosphate in human leukocytes and prevents antigenic release of histamine from cells of allergic donors. Both effects occur at histamine concentrations that can be achieved by antigenic release of the amine in vitro.

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