Latent Herpes Simplex Virus in Spinal Ganglia of Mice

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Science  27 Aug 1971:
Vol. 173, Issue 3999, pp. 843-845
DOI: 10.1126/science.173.3999.843


Herpes simplex virus establishes a persistent, latent infection in spinal ganglia after mice have recovered from posterior paralysis. Infectious virus is replicated when these ganglia are explanted and maintained as organ cultures in vitro.