Dopamine: Release from the Brain in vivo by Amantadine

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Science  22 Oct 1971:
Vol. 174, Issue 4007, pp. 408-410
DOI: 10.1126/science.174.4007.408


After dopamine stores in the caudate nucleus of cats were labeled with [3H]dopamine, the ventricular system was perfused with artificial cerebrospinal fluid. The addition of amantadine to the perfusing fluid caused a doserelated increase in the concentrations of [3H]dopamine appearing in the perfusion effluent. Subthreshold concentrations of amantadine also enhanced the efflux of [3H]dopamine induced by electrical stimulation of the caudate nucleus.