Intestinal Secretion: Stimulation by Peptides

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Science  22 Oct 1971:
Vol. 174, Issue 4007, pp. 422-424
DOI: 10.1126/science.174.4007.422


Two peptides isolated from intestinal mucosa, vasoactive intestinal peptide, and gastric inhibitory peptide, stimulate small intestinal secretion in conscious dogs. Glucagon and pentagastrin also stimulate, but secretin and the octapetide of cholecystokinin do not. The stimulants may participate in regulation of intestinal secretion in health and in diseases with excessive secretion.