Social Behavior of Monkeys Selectively Depleted of Monoamines

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Science  22 Oct 1971:
Vol. 174, Issue 4007, pp. 428-431
DOI: 10.1126/science.174.4007.428


Initiated social interactions of Macaca speciosa are decreased during the period of treatment with alpha-methyl-p-tyrosine, an inhibitor of catecholamine synthesis. The treated animals maintained stable body weights and appeared to be healthy. Similar depletion of indoleamines with p-chlorophenylalanine does not change these same observed behaviors in spite of weight loss, hair loss, ataxia, and debilitation in some of the animals.