Crystal Structure of a Naturally Occurring Dinucleoside Monophosphate: Uridylyl (3',5') Adenosine Hemihydrate

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Science  03 Dec 1971:
Vol. 174, Issue 4013, pp. 1020-1022
DOI: 10.1126/science.174.4013.1020


The crystal structure of uridylyl (3',5') adenosine hemihydrate has been analyzed by x-ray diffraction. The two independent molecules found in the asymmetric unit exhibit conformations that differ significantly from those found in double-helical RNA. The conformational information obtained from this analysis provides considerable insight into the possible conformations of nonhelical "loop" regions of transfer RNA, as well as single-stranded regions of nucleic acids in general.