Snake Neurotoxins: Effect of Disulfide Reduction on Interaction with Electroplax

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Science  17 Dec 1971:
Vol. 174, Issue 4015, pp. 1236-1237
DOI: 10.1126/science.174.4015.1236


Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3'-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.