Suppression of Urethan-Induced Lung Adenomas in Mice Treated with Trehalose-6,6-Dimycolate (Cord Factor) and Living Bacillus Calmette Guérin

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Science  17 Dec 1971:
Vol. 174, Issue 4015, pp. 1240-1242
DOI: 10.1126/science.174.4015.1240


Trehalose-6,6-dimycolate (cord factor), a glycolipid from mycobacteria, suppressed the development of urethan-induced tumors in the lungs of mice to a similar degree as living Mycobacterium bovis (strain BCG) bacilli. The inhibition was apparently due to the host cellular reaction caused locally by cord factor.