1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture

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Science  18 Feb 1972:
Vol. 175, Issue 4023, pp. 768-769
DOI: 10.1126/science.175.4023.768


1,25-Dihydroxycholecalciferol (DHCC), isolated from kidney homogenates incubated with 25-hydroxycholecalciferol (HCC), stimulated the release of previously incorporated 4545Ca from fetal rat bones in organ culture, at concentrations of 10-10 to 10-8M. The dose response curves for 1,25-DHCC and 25-HCC, the parent compound, are parallel, but 1,25-DHCC is about 100 times as potent on a weight basis. Brief exposure to maximum doses of either agent leads to prolonged bone resorption.

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