Δ9-Tetrahydrocannabinol: Aversive Effects in Rat at High Doses

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Science  25 Feb 1972:
Vol. 175, Issue 4024, pp. 911-912
DOI: 10.1126/science.175.4024.911


Water-deprived rats were administered a single dose of Δ9-tetrahydrocannabinol either orally or intraperitoneally immediately after their first taste of a saccharine solution. In tests beginning 47 hours after drug administration, a dose-related reversal of rats' normal preference for saccharine was found. The data suggest that the drug produces aversive effects at doses of 1 to 32 milligrams per kilogram.

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