Feeding Produced in the Satiated Rat by Elevating the Concentration of Calcium in the Brain

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Science  09 Jun 1972:
Vol. 176, Issue 4039, pp. 1124-1125
DOI: 10.1126/science.176.4039.1124


When the concentration of calcium ions in the cerebral ventricles is elevated, a fully satiated rat eats voraciously. This feeding response is not prevented by prior intraventricular administration of alpha-or beta-adrenergic blocking agents, or other pharmacological antagonists. This supports the concept of an independent ionic mechanism, rather than a neurotransmitter one, for modulating a "set-point" for weight or hunger.

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