1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D3 Active on Bone in Anephric Rats

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Science  09 Jun 1972:
Vol. 176, Issue 4039, pp. 1146-1147
DOI: 10.1126/science.176.4039.1146


Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D3 responsible for bone calcium mobilization.

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