Spontaneous Transformation of Human Brain Cells Grown in vitro and Description of Associated Virus Particles

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Science  30 Jun 1972:
Vol. 176, Issue 4042, pp. 1420-1422
DOI: 10.1126/science.176.4042.1420


A human brain cell culture grown in vitro has spontaneously transformed, as determined by morphology, growth characteristics, and karyotype analysis. Virus particles morphologically akin to oncogenic RNA viruses are present in the transformed cells, which are now in subculture 60.

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