Salicylate: A Structure-Activity Study of its Effects on Membrane Permeability

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Science  30 Jun 1972:
Vol. 176, Issue 4042, pp. 1423-1425
DOI: 10.1126/science.176.4042.1423


Salicylate atnd benzoate, and their anlalogs, reversibly increase the membrane potetntial and conductance of identified molluscan neurons by increasing potassium conductance and decreasing chloride conductance. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficients and their pKa values.

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