Somatic Cell Genetic Assignment of Peptidase C and the Rh Linkage Group to Chromosome A-1 in Man

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Science  30 Jun 1972:
Vol. 176, Issue 4042, pp. 1429-1431
DOI: 10.1126/science.176.4042.1429


The segregation of the human peptidase-C phenotype in five different series of human-mouse hybrid clones was examined. The chromosome constitution of these hybrids was determined by quinacrine mustard fluorescence, Giemsa banding, and constitutive heterochromatin staining. That the clones could be classified without exception either as human peptidase C positive/ A-1 positive (14 clones), or as peptidase C negative/ A-1 negative (12 clones) indicates that peptidase C can be assigned to the human A-i chromosome. Data from an extensive series of human-mouse clones used provide support for the syntenic association between peptidase C and phosphoglucomutase-1 and by inference a linkage of both to Rh factor group.

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