Mixed Function Oxidase and Ethanol Metabolism in Perfused Rat Liver

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Science  30 Jun 1972:
Vol. 176, Issue 4042, pp. 1435-1437
DOI: 10.1126/science.176.4042.1435


Oxidation-reduction changes of cytochrome P-450 and oxygen consumption were measured in isolated perfused livers from normal and phenobarbital-treated rats. Phenobarbital treatment markedly increased the aminopyrine-induced reduction of cytochrome P-450, but ethanol did not cause any redox changes of this cytochrome. It was concluded that the microsomal ethanol-oxidizing system has an insignificant role in the metabolism of ethanol in intact liver.

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