11-Hydroxy-Δ9-tetrahydrocannabinol: Pharmacology, Disposition, and Metabolism of a Major Metabolite of Marihuana in Man

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Science  07 Jul 1972:
Vol. 177, Issue 4043, pp. 62-64
DOI: 10.1126/science.177.4043.62


11-Hydroxy-Δ9-tetrahydrocannabinol, administered intravenously to man, produces psychologic and pharmacologic effects that persist for several hours. The drug and its metabolites are excreted in urine and feces for more than 1 week. The pharmacology, disposition, and metabolism of 11-hydroxy-Δ9-tetra-hydrocannabinol mimic that of Δ9-tetrahydrocannabinol, thus providing evidence that Δ9-tetrahydrocannabinol (the major active component of marihuana) is converted to the 11-hydroxy compound in man, the latter compound being responsible for the effects.