Decreased RNA Polymerase Activity in Mammalian Zinc Deficiency

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Science  07 Jul 1972:
Vol. 177, Issue 4043, pp. 68-69
DOI: 10.1126/science.177.4043.68


The activity of DNA-dependent RNA polymerase has been measured in liver nuclei from suckling rats nursed by zinc-deficient dams, or by controls that were either pair-fed or given free access to the diet. In the zinc-deficient pups, the activity of the enzyme did not increase; it fell after the tenth day of life.