Neuroanatomical Correlates of Morphine Dependence

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Science  18 Aug 1972:
Vol. 177, Issue 4049, pp. 616-617
DOI: 10.1126/science.177.4049.616


Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.

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