Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood Leukocytes

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Science  01 Sep 1972:
Vol. 177, Issue 4051, pp. 793-795
DOI: 10.1126/science.177.4051.793


A new soluble mediator was found in supernatant fluid from cultures of human peripheral blood leukocytes that were stimulated by phytohemagglutinin, or by antigenic material present in human dental plaque deposits. This soluble Jactor produced bone resorption in organ cultures of fetal rat bones as measured by increased release of calcium-45, and also increased the number of active osteoclasts.

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