Human Prolactin: 24-Hour Pattern with Increased Release doring Sleep

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Science  29 Sep 1972:
Vol. 177, Issue 4055, pp. 1205-1207
DOI: 10.1126/science.177.4055.1205


Human prolactin was measured in plasma by radioimmunoassay at 20 minute intervals for a 24-hour period in each of six normal adults, whose sleep-wake cycles were monitored polygraphically. A marked diurnal variation in plasma concentrations was demonstrated, with highest values during sleep; periods of episodic release occurred throughout the 24 hours.

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