Thyrotropin Releasing Hormone: Enhancement of Dopa Activity by a Hypothalamic Hormone

See allHide authors and affiliations

Science  27 Oct 1972:
Vol. 178, Issue 4059, pp. 417-418
DOI: 10.1126/science.178.4059.417


Thyrotropin releasing hormone potentiates the behaviorial effects of dopa plus pargyline in mice. Because the potentiation occurs in hypophysectomized mice, as well as in normal mice, the phenomenon is independent of the release of thyroid stimulating hormone from the pituitary. Possible mechanisms and clinical implications are discussed.