Coherin: A New Peptide of the Bovine Neurohypophysis with Activity on Gastrointestinal Motility

See allHide authors and affiliations

Science  27 Oct 1972:
Vol. 178, Issue 4059, pp. 419-421
DOI: 10.1126/science.178.4059.419


A factor with potent activity in the regulation of mammalian gastrointestinal motor function has been isolated from the bovine posterior pituitary gland by a process allowing minimal dissociation of neurophysin-bound complexes and the separation of free unbound peptides. This substance alters the frequency, amplitude, rhythm, and duration of peristaltic contraction.