Mitochondrial Polyriboadenylate Polymerase: Relative Lack of Activity in Hepatomas

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Science  10 Nov 1972:
Vol. 178, Issue 4061, pp. 639-640
DOI: 10.1126/science.178.4061.639


An enzyme that polymerizes adenylate residues from adenosine triphosphate was prepared from rat liver mitochondria and compared to similar preparations from the mitochondria of three hepatomas. Enzyme activity in the hepatomas was only 1 to 2 percent of that in normal liver.