Thymus-Dependent and Thymus-Independent Lymophocyte Separation: Relation to Exposed Sialic Acid on Cell Surface

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Science  01 Dec 1972:
Vol. 178, Issue 4064, pp. 1001-1002
DOI: 10.1126/science.178.4064.1001


On preparative cell electrophoresis mouse lymph node lymphocytes separate into fast-moving (T, thymus-dependent) and slow-moving (B, thymus-independent) fractions. After treatment with neuraminidase all lymphocytes move as one very slow fraction, indicating that the difference in the mobility of the two kinds of cells is due to differences in the density of exposed sialic acid on their surfaces.

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