Amino Acid Neurotransmitter Candidates: Sodium-Dependent High-Affinity Uptake by Unique Synaptosomal Fractions

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Science  01 Dec 1972:
Vol. 178, Issue 4064, pp. 997-999
DOI: 10.1126/science.178.4064.997


Glutamic and aspartic acids and glycine are accumulated by high-affinity uptake systems into synaptosomal preparations in central nervous tissue. Sodium is required by these high-affinity transports, but not by the low-affinity transports for these and other amino acids. The sodium-requiring amino acid uptake systems label unique synaptosomal fractions. Observations suggest that these amino acids serve specific synaptic functions, presumably as neurotransmitters.

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