Direct Phase Determination from Neutron Diffraction Data of the Structure of Melampodin

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Science  22 Dec 1972:
Vol. 178, Issue 4067, pp. 1282-1283
DOI: 10.1126/science.178.4067.1282


The structure of a large complex molecule, C21H24O9, has been solved directly from neutron diffraction data by using sigma-2 and tangent refinement methods. As a consequence, the neutron diffraction technique must be reevaluated as a possible primary tool for crystal structure determination.