Evidence for Active Immunity to Morphine in Mice

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Science  22 Dec 1972:
Vol. 178, Issue 4067, pp. 1290-1292
DOI: 10.1126/science.178.4067.1290


The serum from mice actively immunized with a morphine immunogen contained antibodies that could bind dihydromorphine. Morphine effects were diminished in these "immunized" mice, and the concentration of morphine in their plasma was altered.