Implantation of Exogenous Enzymatic Activity in Isolated Alveolar Macrophages

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Science  22 Dec 1972:
Vol. 178, Issue 4067, pp. 1302-1304
DOI: 10.1126/science.178.4067.1302


Alveolar macrophages acquired the capacity to oxidize uric acid after exposure to uricase. Presumably this resulted from intracellular incorporation of the enzyme by endocytosis. This approach may provide a general method for (i) testing regulatory biochemical mechanisms, (ii) therapeutic replacement of deficient regulatory macromolecules, and (iii) studying environmental factors that produce genetic alterations.