Urinary Catecholamine Metabolites during Behavioral Changes in a Patient with Manic-Depressive Cycles

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Science  19 Jan 1973:
Vol. 179, Issue 4070, pp. 300-302
DOI: 10.1126/science.179.4070.300


3-Methoxy-4-hydroxyphenylglycol and normetanephrine were analyzed in daily urine specimens of a patient with manic-depressive cycles who was studied longitudinally. The quantities of these catecholamine metabolites excreted into urine were decreased during periods of depression as compared with periods of mania. Urinary excretion of 3-methoxy-4-hydroxyphenylglycol varied cyclically with a period length of approximately 20 days. Changes in this metabolite, and perhaps in normetanephrine, preceded the affective and behavioral shifts.