Delta-9-Tetrahydrocannabinol: Localization in Body Fat

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Science  26 Jan 1973:
Vol. 179, Issue 4071, pp. 391-393
DOI: 10.1126/science.179.4071.391


[14C9-Tetrahydrocannabinol9THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Δ9THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Δ9THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Δ9THC and its metabolites accumulated in fat and brain.

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