Aqueous Central Cavity in Aspartate Transcarbamylase from Escherichia coli

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Science  16 Feb 1973:
Vol. 179, Issue 4074, pp. 683-685
DOI: 10.1126/science.179.4074.683


A three-dimensional x-ray diffraction study of aspartate transcarbamylase to 5.5-angstrom resolution, with the aid of four isomorphous heavy atom derivatives, indicates the presence of a central aqueous cavity approximating an oblate spheroid about 25 by 50 by 50 angstroms in dimension, within a molecule about 90 by 110 by 110 angstroms in largest dimensions.