Myelination Inhibition Factor: Dissociation from Induction of Experimental Allergic Encephalomyelitis

See allHide authors and affiliations

Science  16 Feb 1973:
Vol. 179, Issue 4074, pp. 689-690
DOI: 10.1126/science.179.4074.689


Sensitization of guinea pigs with purified myelin basic protein induces experimental allergic encephalomyelitis (EAE) but does not induce a serum factor which inhibits myelin formation in vitro. This factor, induced by some unidentified constituent of whole central nervous system tissue, should not be characterized as a component of "EAE serum."