Association of the HL-A7 Cross-Reacting Group with a Specific Reaginic Antibody Response in Allergic Man

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Science  16 Feb 1973:
Vol. 179, Issue 4074, pp. 691-693
DOI: 10.1126/science.179.4074.691


A relatively small proportion (17 percent) of individuals highly allergic to ragweed were found to develop marked reaginic (immunoglobulin E-mediated) skin sensitivity to a minor ragweed pollen allergen Ra5 (molecular weight 5200). Sensitivity to Ra5 was significantly associated with the possession of a major histocompatibility antigen of the HL-A7 cross-reacting group. This appears to be the first evidence of a strong association between a specific immune response and a specific group of closely related HL-A antigens in man.