Strychnine- and Pentylenetetrazol-Induced Changes of Excitability in Aplysia Neurons

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Science  16 Mar 1973:
Vol. 179, Issue 4078, pp. 1133-1136
DOI: 10.1126/science.179.4078.1133


In Aplysia neurons isolated from their synaptic input strychnine induces doublet discharges associated in voltage clamp with a decrease in the threshold for the inward current and a reduction and delayed onset of the outward current. Pentylenetetrazol causes oscillations and bursting behavior in normally silent cells together with an increased inactivation of the delayed outward current and induced or enhanced anomalous rectification.