Camptothecin Blocks Memory of Conditioned Avoidance in the Goldfish

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Science  23 Mar 1973:
Vol. 179, Issue 4079, pp. 1243-1246
DOI: 10.1126/science.179.4079.1243


Intracranial injection of 10 to 75 micrograms of camptothecin, a plant alkaloid that blocks RNA synthesis in eucaryotic cells, blocks incorporation of tritiated uridine into RNA in the goldfish brain. Injection of 10 to 50 micrograms of the drug within 1.5 hours of training results in greatly diminished memory, tested 1 week later. Injection of the drug 5 or 24 hours after training produces no measurable effect on retention of the learned response.