Vasopressin: Possible Role of Microtubules and Microfilaments in Its Action

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Science  27 Jul 1973:
Vol. 181, Issue 4097, pp. 347-350
DOI: 10.1126/science.181.4097.347


Colchicine, vinblastine, podophyllotoxin, and cytochalasin B inhibit the action of vasopressin and cyclic adenosine monophosphate on osmotic water movement across the toad bladder. The findings suggest that microtubules, and possibly microfilaments, play a role in the action of vasopressin, perhaps through involvement in the mechanism of release of secretory material from the bladder epithelial cells.